About the Foundation

The DNA Resonance Research Foundation is an independent nonprofit research organization based in San Diego, California, established in 2018. Our mission is to advance understanding of genome organization and function through computational and biophysical approaches.

Research Focus

Our primary research objective is to elucidate the role of transposable elements and noncoding genomic regions in chromatin folding and cellular differentiation. We employ computational genomics methods to analyze genomic sequence data, with particular emphasis on repetitive elements including Alu and LINE1 transposons.

Our work integrates genome-wide sequencing data analysis with biophysical modeling to understand how DNA sequence influences three-dimensional chromatin organization. This research has implications for gene regulation, developmental biology, and the functional interpretation of the noncoding genome.

The foundation conducts both computational analyses of large-scale genomic datasets and experimental validation of computational predictions. Our computational infrastructure supports analysis of whole-genome sequencing data, including publicly available datasets from initiatives such as the Human Pangenome Reference Consortium.

Current Projects

We are investigating sequence-specific DNA dynamics and their relationship to chromatin structure. Current projects include:

• Computational identification of genomic elements with distinctive biophysical properties

• Analysis of transposon distribution patterns and their correlation with chromatin domains

• Development of predictive models for chromatin folding based on DNA sequence features

• Integration of genomic, epigenomic, and three-dimensional chromatin organization data

Funding

The foundation operates through private funding dedicated exclusively to research activities. All findings are published in peer-reviewed scientific literature and made available to the research community.

Publications

For a complete list of publications, please visit our Publications page.

Data Access Requests

As part of our computational genomics research program, we access controlled-tier genomic datasets through appropriate data access agreements with repositories including dbGaP, EGA, and the NIH All of Us Research Program. All data handling complies with relevant data use limitations and privacy protections.

Contact

Principal Investigator: Max Rempel, Ph.D.
Email: max@dnaresonance.org
Phone: +1 (585) 705-1400
San Diego, CA 92111, USA